Whole-cell Martini model

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Last Updated: Wednesday, 18 January 2023 08:34

We got him ! Together with the group of Zan Luthey-Schulten we modeled an entire cell (JCVI-Syn3a) at the Martini level of resolution. Featuring more than 60,000 proteins, millions of lipids and metabolites, 500 ribosomes and a 500 kbp circular dsDNA.

For details, read our perspective paper: Stevens et al., 'Molecular dynamics simulation of an entire cell', Frontiers in Chemistry, vol 11, 2023. https://doi.org/10.3389/fchem.2023.1106495

 

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Open positions on multiscale modeling at whole-cell level

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Last Updated: Monday, 19 December 2022 13:10

Interested in simulating entire cells and cell organelles ?

Or rather keen on improving the Martini force field and associated multiscale tools ?

Then join our team !

Apply now for a PhD (4yr) or post-doc position (2yr) in the Molecular Dynamics group at the University of Groningen, The Netherlands, headed by Prof. Siewert-Jan Marrink.

To apply, please send your CV and motivation letter as well as names of two references to This email address is being protected from spambots. You need JavaScript enabled to view it..

Deadline: Jan 31st, 2023.

Positions can be filled at any time in 2023.

Vesicles under attack

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Last Updated: Monday, 05 December 2022 16:06

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Curious to find out what happens here to a poor (Dry Martini) vesicle ?

Check the paper from Wiemann, Nguyen et al., iScience 2022.

Martini Retreat

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Last Updated: Wednesday, 23 November 2022 18:13

Two weeks ago we had a wonderful meeting on Malta, uniting some of the core groups working on Martini development. 

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AI meets Martini

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Last Updated: Tuesday, 01 November 2022 10:32

Impressive ! Discovering self-assembling pentapeptides, combining high-throughput Martini simulations with an AI workflow. The AI workflow outperforms human-based selection of optimal pentapeptide sequences from more than 3 million possible mutations. For details, see Batra et al., Nature Chem, 2022.

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